Ziyi Guo
University of New South Wales, Australia
Title: Multifunctional biocatalytic submarine-like micromotors for directional vertical motion
Biography
Biography: Ziyi Guo
Abstract
Artificial and micro/nano biohybrids have emerged as an exciting branch of research at the interface of materials engineering and biological science. People have found vast potential for applications ranging from nanomedicine to environmental remediation. Among the biohybrids, self-propelled artificial micromotors have been extensively investigated in the last few years, showing promise for controlled drug delivery, sensors, environmental remediation, and micromanipulation. As we advance toward real-world applications, steering of the motors to a specific destination and with speed regulation will be required.
Here, we report for the first time the design of a novel submarine-like micromotor that is capable of regulating its buoyancy force to achieve reversible, corporative directional vertical motion in centimeter-scale. Guided by density functional theory (DFT) calculations, we synthesized a composite metal-organic framework (MOF)-based micromotor system containing a bioactive enzyme as the engine for gas bubble generation and a pH-responsive, hydrophilic/hydrophobic phase-shifting polymer as the gear to tune the micromotor buoyancy force through modulated interaction with the produced gas bubbles. Importantly, anti-cancer drug-loaded micromotors showed directional cytotoxicity to the three-dimensional cell cultures, depending on the pH of the cellular environment. We found that such facile and versatile method for exploring novel driving forces for motion manipulation could be further applied to colloidal science and electrochemistry, showing potential as smart cargo transport microsystems that could accomplish more challenging tasks by exploiting the complex biological environment.